News story miscasts Alzheimer’s science | Science
As experienced researchers in the Alzheimer’s disease field, we have serious concerns about the News story “Blots on a field?” (C. Piller, 22 July, https://scim.ag/3T1evDh). The article summarizes the apparent manipulation of data in a 2006 study (1) and suggests that coauthor Sylvain Lesné committed egregious scientific misconduct when preparing figures supporting a central role for the specific amyloid-β (Aβ) peptide, Aβ*56, in memory loss in mouse models of Alzheimer’s disease. Such investigative reporting is important to correct potential fraud. However, the article overstates and distorts the effect of this paper on the Alzheimer’s field.